The following is a timeline charting her rise to the top of the women's game:
With an unrestrained jig at the most hallowed hallway in tennis, Serena Williams confirmed that 'Her Way' was just about the most formidable method the women's game has seen.
Serena Williams outplayed Maria Sharapova to claim the 2015 Australian Open championship in straight sets on Saturday.
Serena Williams made a triumphant return to the WTA Tour on Thursday, crushing China's Zhang Shuai 6-2, 6-3 in the second round of the Sony Ericsson Open in Miami.
World No 1 and top seed Serena Williams was knocked out of the Australian Open by Serbian Ana Ivanovic on Sunday.
Factbox on American Serena Williams, who won her 15th Grand Slam singles title at the US Open on Sunday with a 6-2, 2-6, 7-5 win over Victoria Azarenka of Belarus.
World No 1 Serena Williams, coming off a surprise third round loss at Wimbledon, heads the women's field for the US Open, which starts in New York in late August.
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The World No 1 becomes earliest qualifier for WTA Finals
Serena Williams is third on the list of female Grand Slam title winners. She is one of only five women, after Maureen Connolly, Margaret Court, Martina Navratilova and Steffi Graf, to hold all four Grand Slam titles at same time.
Even though she won four big titles during the year, Serena Williams will still end 2012 ranked No 3 behind Victoria Azarenka and Maria Sharapova. After backing up her victories at Wimbledon, the Olympics and the US Open with the WTA Championships title on Sunday, Williams concurred with Sharapova and World No 8 Li Na that she is in fact the world's top female tennis player.
"It's kind of hard to say because she -- there's nothing I did wrong on those match points," Williams told reporters after her bid for a record-equalling 24th Grand Slam title ended.
Tennis sensation Serena Williams flaunted her toned figure while on a holiday in Miami to celebrate her French Open win.
Sister Venus, actress Eva Longoria; singer Ciara, singer Kelly Rowland, of Destiny's Child fame and wife of New York Knicks' star Carmelo Anthony, LaLa, were the group of girls who were part of the soiree that was held at a local diner in Florida.
The 23 time Grand Slam champion made not one but two appearances at the Oscars on Sunday night.
Serena Williams reluctantly pulled out of this year's Australian Open on Friday, the American saying that while she was close to regaining full fitness after giving birth to her first child in September, she was not fully ready to defend her title.
Tennis ace Serena Williams has graced the cover of the Essence magazine's July 2013 'Body Issue' in a blue ombre swimsuit.
Serena Williams won her eighth Miami Open title with little trouble, enjoying a 6-2, 6-0 win over Spain's Carla Suarez Navarro in just 56 minutes on Saturday.
The older Serena Williams gets, the more dominant she becomes. At 33, an age when most players start to fade, her grip on women's tennis looks as secure as ever.
A pregnant Serena Williams makes the tennis superstar even more attractive to corporate sponsors, allowing her to extend her reach into maternity wear and motherhood products, sponsorship industry executives said.
Defending champion Thomas Johansson of Sweden is injured and won't be defending his title at the Australian Open.
Defending champion Serena Williams battled to a 3-6, 7-5, 6-3 victory over world number four Svetlana Kuznetsova to reach the Sony Ericsson Open final on Thursday. The American, who had to cope with back trouble along with the hot and humid conditions, is bidding to equal Steffi Graf's record of five title successes in the tournament.
Serena Williams won her second straight tournament and proved her mettle ahead of the U.S. Open with a convincing 6-4, 6-2 win over Australia's Samantha Stosur in the Toronto Cup final on Sunday.
Serbia's Novak Djokovic has beaten Andy Murray to the International Tennis Federation's (ITF) annual men's World Champion award with American Serena Williams taking the women's prize for a third time.
Following is a list of American Serena Williams' 22 grand slam singles titles as she equalled Steffi Graf's professional era record with victory at Wimbledon on Saturday
Australia's Hewitt earned the accolade for the second year running, while American Williams was honoured for the first time.
The powerful Serena Williams may be the 'best player' but World No 2 Victoria Azarenka insists that she is steadily closing the gap.
Fourth seeded Williams beat Serbian second seed Jelena Jankovic in straight sets to win her third US Open crown and ninth Grand Slam title.
Top-seeded Serena Williams said on Friday that she was not sure about the state of her balky right shoulder but felt more relaxed entering next week's US Open than last year.
Defending champion Carlos Alcaraz made a strong return to competitive tennis after a five-month wrist injury layoff, defeating Roman Safiullin 6-4, 6-4, 6-4 in the first round of the US Open, showcasing his powerful forehand with over 20 winners.
Serena Williams has never been one to take too much notice of convention.
Champion Serena Williams has withdrawn from January's Australian Open as she struggles to recover from a foot injury, which has sidelined her since July, organisers said on Thursday.
World No 1 Serena Williams and her sister Venus tried their hand at cricket with the Melbourne Renegades players on a hotel roof top on Thursday.
Serena Williams has clinched the year-end women's World No 1 ranking for the third time in her career after winning two Grand Slam titles during an excellent 2013.
Former World No 1 Kim Clijsters says, "I admire both Serena and Venus because they have a perseverance that is incredible. They're able to do a lot of things that other people can't do, physically and mentally, so I don't doubt that she will come back, I don't doubt it, but it just takes a little bit of time."
Aryna Sabalenka began her quest for a third successive US Open title with a dominant win against Colombia's Camila Osorio.
Australian Open winner Serena Williams has pulled out of next week's German Open in Berlin, the organisers said on Wednesday.
Victoria Azarenka won a showdown between the world's two top players by beating number one Serena Williams in a three set 2-6, 6-2, 7-6 thriller in the final of the Western and Southern Open on Sunday.
Serena Williams defeated Belgium's Justine Henin 6-4, 3-6, 6-2 on Saturday to win the Australian Open for the fifth time after a match of unrelenting tension between the two best players of their generation.
Serena Williams has re-entered the tennis anti-doping testing pool but the 23-times Grand Slam champion denied on Tuesday that the move had anything to do with her making a return to the sport she dominated for nearly two decades.
